† Patients received alternating cycles of AVb and CMF. Consider the use of dexrazoxane to reduce the incidence and severity of cardiomyopathy due to doxorubicin administration in patients who have received a cumulative doxorubicin dose of 300 mg/m2 and who will continue to receive doxorubicin. A dose-dependent, reversible neutropenia is the predominant manifestation of hematologic toxicity from doxorubicin. Tachyarrhythmias, including sinus tachycardia, premature ventricular contractions, and ventricular tachycardia, as well as bradycardia may occur. At the time of the meta-analysis, 1745 first recurrences and 1348 deaths had occurred. Each 2 mg/mL, 100 mL (200 mg) multiple dose vial contains 200 mg Doxorubicin Hydrochloride, USP; Sodium Chloride 0.9% (to adjust tonicity) and Water for Injection q.s. You may have red colored urine for 1 to 2 days after your infusion of Doxorubicin. The recommended dose of doxorubicin when used as a single agent is 60 to 75 mg/m, The recommended dose of doxorubicin, when administered in combination with other chemotherapy drugs, is 40 to 75 mg/m. The distribution half-life is approximately 5 minutes, while the terminal half-life is 20 to 48 hours. The exact mechanism of the interaction is unknown, but decreased absorption or accelerated elimination of carbamazepine may be the cause. Each 2 mg/mL, 10 mL (20 mg) vial contains 20 mg Doxorubicin Hydrochloride, USP; Sodium Chloride 0.9% (to adjust tonicity) and Water for Injection q.s. The relative exposure of doxorubicinol, i.e., the ratio between the AUC of doxorubicinol and the AUC of doxorubicin is approximately 0.5. We know it’s a worrying time for people with cancer, we have information to help. Figure 1. The mechanism of doxorubicin is intercalated with the DNA and inhibits topoisomerase 2. In a randomized trial in women with metastatic breast cancer, initiation of dexrazoxane with doxorubicin based chemotherapy resulted in a significantly lower tumor response rate (48% vs. 63%; p=0.007) and shorter time to progression than in women who received doxorubicin based chemotherapy alone. The patient was treated with antibiotics and platelets and recovered 18 days after overdose. Advise patients to contact their healthcare provider if they become pregnant, or if pregnancy is suspected, while taking doxorubicin [see Use in Specific Populations (8.1)]. Immunisation against infectious disease: Chapter 6: General contraindications to vaccination, First published: March 2013 and regularly updated on the Gov.UK website. Inactive ingredients for Doxorubicin Hydrochloride For Injection: lactose and methylparaben. Clinically significant interactions have been reported with inhibitors of CYP3A4, CYP2D6, and/or P-gp (e.g., verapamil), resulting in increased concentration and clinical effect of doxorubicin. Doxorubicin may cause serious side effects, including: Doxorubicin may cause lower sperm counts and sperm problems in men. 1999 Apr 1;57(7):727-41. doi: 10.1016/s0006-2952(98)00307-4. with lower risk of disease recurrences or death compared to the treatment with CMF. Extravasation and Tissue Necrosis: Extravasation of doxorubicin can result in severe local tissue injury and necrosis requiring wide excision of the affected area and skin grafting.Immediately terminate the drug, and apply ice to the affected area [see Warnings and Precautions (5.3)]. MIMS Class . This is called intravesical chemotherapy and the side effects are different to doxorubicin given into a vein. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. 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